EXTH-30. PRECEDING p53 STABILIZATION USING DOXORUBICIN AUGMENTS PRIMA-1-MEDIATED p53 REFOLDING AND INCREASED CELLULAR APOPTOSIS: EVALUATION OF A SEQUENTIAL COMBINATION THERAPY AGAINST GLIOBLASTOMA

INTRODUCTION: Mutant p53 cancer cells are poorly responsive to chemotherapy. A small molecule drug, PRIMA-1, can bind to wildtype and mutant p53 to induce structural conformation that enhances p53 DNA binding. In a quest for new effective combination chemotherapies, we hypothesized that sequential t...

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Vydáno v:Neuro Oncol
Hlavní autoři: Babikir, Husam, Afjei, Rayhaneh, Paulmurugan, Ramasamy, Massoud, Tarik
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847763/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.362
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