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A transgenic mouse model expressing an ERα folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling

Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of E...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sekar, Thillai V., Foygel, Kira, Massoud, Tarik F., Gambhir, Sanjiv S., Paulmurugan, Ramasamy
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056407/
https://ncbi.nlm.nih.gov/pubmed/27721470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34788
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