The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical properties of the syndromic mutant Cx26G12R (G...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Gen Physiol
Egile Nagusiak: García, Isaac E., Villanelo, Felipe, Contreras, Gustavo F., Pupo, Amaury, Pinto, Bernardo I., Contreras, Jorge E., Pérez-Acle, Tomás, Alvarez, Osvaldo, Latorre, Ramon, Martínez, Agustín D., González, Carlos
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940247/
https://ncbi.nlm.nih.gov/pubmed/29643172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711782
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