Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins

Connexins (Cxs) are a family of membrane-spanning proteins that form gap junction channels and hemichannels. Connexin-based channels exhibit two distinct voltage-dependent gating mechanisms termed slow and fast gating. Residues located at the C terminus of the first transmembrane segment (TM-1) are...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Pinto, Bernardo I., García, Isaac E., Pupo, Amaury, Retamal, Mauricio A., Martínez, Agustín D., Latorre, Ramón, González, Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957056/
https://ncbi.nlm.nih.gov/pubmed/27143357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709402
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