The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical properties of the syndromic mutant Cx26G12R (G...

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Bibliografski detalji
Izdano u:J Gen Physiol
Glavni autori: García, Isaac E., Villanelo, Felipe, Contreras, Gustavo F., Pupo, Amaury, Pinto, Bernardo I., Contreras, Jorge E., Pérez-Acle, Tomás, Alvarez, Osvaldo, Latorre, Ramon, Martínez, Agustín D., González, Carlos
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2018
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940247/
https://ncbi.nlm.nih.gov/pubmed/29643172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711782
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