The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical properties of the syndromic mutant Cx26G12R (G...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: García, Isaac E., Villanelo, Felipe, Contreras, Gustavo F., Pupo, Amaury, Pinto, Bernardo I., Contreras, Jorge E., Pérez-Acle, Tomás, Alvarez, Osvaldo, Latorre, Ramon, Martínez, Agustín D., González, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940247/
https://ncbi.nlm.nih.gov/pubmed/29643172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711782
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