The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical properties of the syndromic mutant Cx26G12R (G...

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Vydáno v:J Gen Physiol
Hlavní autoři: García, Isaac E., Villanelo, Felipe, Contreras, Gustavo F., Pupo, Amaury, Pinto, Bernardo I., Contreras, Jorge E., Pérez-Acle, Tomás, Alvarez, Osvaldo, Latorre, Ramon, Martínez, Agustín D., González, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940247/
https://ncbi.nlm.nih.gov/pubmed/29643172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711782
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