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Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules

Protein tyrosine phosphatases (PTPs), which catalyze the dephosphorylation of phosphotyrosine in protein substrates, are important cell-signaling regulators, as well as potential drug targets for a range of human diseases. Chemical tools for selectively targeting the activities of individual PTPs wo...

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Pubblicato in:Bioorg Med Chem
Autori principali: Korntner, Samuel, Pomorski, Adam, Krężel, Artur, Bishop, Anthony C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935566/
https://ncbi.nlm.nih.gov/pubmed/29673715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.026
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