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The Allosteric Site on SHP2’s Protein Tyrosine Phosphatase Domain is Targetable with Druglike Small Molecules
[Image: see text] Difficulties in developing active-site-directed protein tyrosine phosphatase (PTP) inhibitors have led to the perception that PTPs are “undruggable”, highlighting the need for new means to target pharmaceutically important PTPs allosterically. Recently, we characterized an alloster...
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| Izdano u: | ACS Omega |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2018
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6275946/ https://ncbi.nlm.nih.gov/pubmed/30533581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b02200 |
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