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Activation of engineered protein tyrosine phosphatases with the biarsenical compound AsCy3-EDT(2)
Methods for activating signaling enzymes hold significant potential for the study of cellular signal transduction. Here we present a strategy for engineering chemically activatable protein tyrosine phosphatases (actPTPs). To generate actPTP1B, we introduced three cysteine point mutations in the enzy...
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| 出版年: | Chembiochem |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5923034/ https://ncbi.nlm.nih.gov/pubmed/28745017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700253 |
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