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Specific inhibition of sensitized protein tyrosine phosphatase 1B (PTP1B) with a biarsenical probe
Protein tyrosine phosphatase 1B (PTP1B) is a key regulator of the insulin-receptor and leptin-receptor signaling pathways, and it has therefore emerged as a critical anti-type-II-diabetes and anti-obesity drug target. Toward the goal of generating a covalent modulator of PTP1B activity that can be u...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288891/ https://ncbi.nlm.nih.gov/pubmed/22263876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200562y |
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