Rational Design of Pyridyl Derivatives of Vanillin for the Treatment of Sickle Cell Disease

Hypoxia-induced polymerization of sickle hemoglobin (Hb S) is the principal phenomenon that underlays the pathophysiology and morbidity associated with sickle cell disease (SCD). Opportunely, as an allosteric protein, hemoglobin (Hb) serves as a convenient and potentially critical druggable target....

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Bibliographic Details
Published in:Bioorg Med Chem
Main Authors: Pagare, Piyusha P., Ghatge, Mohini S., Musayev, Faik N., Deshpande, Tanvi M., Chen, Qiukan, Braxton, Courtney, Kim, Solyi, Venitz, Jürgen, Zhang, Yan, Abdulmalik, Osheiza, Safo, Martin K.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935541/
https://ncbi.nlm.nih.gov/pubmed/29655608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.015
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