Rational Design of Pyridyl Derivatives of Vanillin for the Treatment of Sickle Cell Disease

Hypoxia-induced polymerization of sickle hemoglobin (Hb S) is the principal phenomenon that underlays the pathophysiology and morbidity associated with sickle cell disease (SCD). Opportunely, as an allosteric protein, hemoglobin (Hb) serves as a convenient and potentially critical druggable target....

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Pagare, Piyusha P., Ghatge, Mohini S., Musayev, Faik N., Deshpande, Tanvi M., Chen, Qiukan, Braxton, Courtney, Kim, Solyi, Venitz, Jürgen, Zhang, Yan, Abdulmalik, Osheiza, Safo, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935541/
https://ncbi.nlm.nih.gov/pubmed/29655608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.015
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