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Rational Design of Pyridyl Derivatives of Vanillin for the Treatment of Sickle Cell Disease

Hypoxia-induced polymerization of sickle hemoglobin (Hb S) is the principal phenomenon that underlays the pathophysiology and morbidity associated with sickle cell disease (SCD). Opportunely, as an allosteric protein, hemoglobin (Hb) serves as a convenient and potentially critical druggable target....

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Pagare, Piyusha P., Ghatge, Mohini S., Musayev, Faik N., Deshpande, Tanvi M., Chen, Qiukan, Braxton, Courtney, Kim, Solyi, Venitz, Jürgen, Zhang, Yan, Abdulmalik, Osheiza, Safo, Martin K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935541/
https://ncbi.nlm.nih.gov/pubmed/29655608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.015
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