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Rational Design of Pyridyl Derivatives of Vanillin for the Treatment of Sickle Cell Disease

Hypoxia-induced polymerization of sickle hemoglobin (Hb S) is the principal phenomenon that underlays the pathophysiology and morbidity associated with sickle cell disease (SCD). Opportunely, as an allosteric protein, hemoglobin (Hb) serves as a convenient and potentially critical druggable target....

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Publicat a:Bioorg Med Chem
Autors principals: Pagare, Piyusha P., Ghatge, Mohini S., Musayev, Faik N., Deshpande, Tanvi M., Chen, Qiukan, Braxton, Courtney, Kim, Solyi, Venitz, Jürgen, Zhang, Yan, Abdulmalik, Osheiza, Safo, Martin K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935541/
https://ncbi.nlm.nih.gov/pubmed/29655608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.04.015
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