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Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation
Increasing the affinity of hemoglobin for oxygen represents a feasible and promising therapeutic approach for sickle cell disease by mitigating the primary pathophysiological event, i.e. the hypoxia-induced polymerization of sickle hemoglobin (Hb S) and the concomitant erythrocyte sickling. Investig...
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| 出版年: | Acta Crystallogr D Struct Biol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
International Union of Crystallography
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6173052/ https://ncbi.nlm.nih.gov/pubmed/30289405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318009919 |
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