Crystal Structure of Carbonmonoxy Sickle Hemoglobin in R-state Conformation

The fundamental pathophysiology of sickle cell disease is predicated by the polymerization of deoxygenated (T-state) sickle hemoglobin (Hb S) into fibers that distort red blood cells into the characteristic sickle shape. The crystal structure of deoxygenated Hb S (DeoxyHb S) and other studies sugges...

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Publicat a:J Struct Biol
Autors principals: Ghatge, Mohini S., Ahmed, Mostafa H., Omar, Abdel Sattar M., Pagare, Piyusha P., Rosef, Susan, Kellogg, Glen E., Abdulmalik, Osheiza, Safo, Martin K.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859812/
https://ncbi.nlm.nih.gov/pubmed/27085422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2016.04.003
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