Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

Increasing the affinity of hemoglobin for oxygen represents a feasible and promising therapeutic approach for sickle cell disease by mitigating the primary pathophysiological event, i.e. the hypoxia-induced polymerization of sickle hemoglobin (Hb S) and the concomitant erythrocyte sickling. Investig...

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Bibliographic Details
Published in:Acta Crystallogr D Struct Biol
Main Authors: Deshpande, Tanvi M., Pagare, Piyusha P., Ghatge, Mohini S., Chen, Qiukan, Musayev, Faik N., Venitz, Jurgen, Zhang, Yan, Abdulmalik, Osheiza, Safo, Martin K.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2018
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173052/
https://ncbi.nlm.nih.gov/pubmed/30289405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318009919
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