Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease

Candidate drugs to counter intracellular polymerization of deoxygenated sickle hemoglobin (Hb S) continue to represent a promising approach to mitigating the primary cause of the pathophysiology associated with sickle cell disease (SCD). One such compound is the naturally occurring antisickling agen...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Xu, Guoyan G., Pagare, Piyusha P., Ghatge, Mohini S., Safo, Ronni P., Gazi, Aheema, Chen, Qiukan, David, Tanya, Alabbas, Alhumaidi B., Musayev, Faik N., Venitz, Jürgen, Zhang, Yan, Safo, Martin K., Abdulmalik, Osheiza
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871537/
https://ncbi.nlm.nih.gov/pubmed/28858508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00553
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