VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

Sickle cell disease (SCD) results from a hemoglobin (Hb) mutation βGlu6 → βVal6 that changes normal Hb (HbA) into sickle Hb (HbS). Under hypoxia, HbS polymerizes into rigid fibers, causing red blood cells (RBCs) to sickle; leading to numerous adverse pathological effects. The RBC sickling is made wo...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Abdulmalik, Osheiza, Pagare, Piyusha P., Huang, Boshi, Xu, Guoyan G., Ghatge, Mohini S., Xu, Xiaomeng, Chen, Qiukan, Anabaraonye, Nancy, Musayev, Faik N., Omar, Abdelsattar M., Venitz, Jürgen, Zhang, Yan, Safo, Martin K.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679387/
https://ncbi.nlm.nih.gov/pubmed/33219275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77171-2
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