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Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling
The T cell costimulatory receptor CD28 is required for the full activation of naïve T cells and for the development and maintenance of Foxp3(+) regulatory T (T(reg)) cells. We showed that the cytoplasmic domain of CD28 was bound to the plasma membrane in resting cells and that ligand binding to CD28...
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| Publicado en: | Sci Signal |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5929992/ https://ncbi.nlm.nih.gov/pubmed/27460989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf0626 |
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