Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

The Src family tyrosine kinases Lck and Fyn are critical for signaling via the T cell receptor. However, the exact mechanism of their activation is unknown. Recent crystal structures of Src kinases suggest that an important mechanism of kinase activation is via engagement of the Src homology (SH)3 d...

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Detalhes bibliográficos
Main Authors: Holdorf, Amy D., Green, Jonathan M., Levin, Steven D., Denny, Michael F., Straus, David B., Link, Vinzenz, Changelian, Paul S., Allen, Paul M., Shaw, Andrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195584/
https://ncbi.nlm.nih.gov/pubmed/10430626
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