Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain

Lymphocyte-specific protein-tyrosine kinase (Lck) plays an essential role in T cell receptor (TCR) signaling and T cell development, but its activation mechanism is not fully understood. To explore the possibility that plasma membrane (PM) lipids control TCR signaling activities of Lck, we measured...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Sheng, Ren, Jung, Da-Jung, Silkov, Antonina, Kim, Hyunjin, Singaram, Indira, Wang, Zhi-Gang, Xin, Yao, Kim, Eui, Park, Mi-Jeong, Thiagarajan-Rosenkranz, Pallavi, Smrt, Sean, Honig, Barry, Baek, Kwanghee, Ryu, Sungho, Lorieau, Justin, Kim, You-Me, Cho, Wonhwa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016160/
https://ncbi.nlm.nih.gov/pubmed/27334919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720284
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