Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain

Lymphocyte-specific protein-tyrosine kinase (Lck) plays an essential role in T cell receptor (TCR) signaling and T cell development, but its activation mechanism is not fully understood. To explore the possibility that plasma membrane (PM) lipids control TCR signaling activities of Lck, we measured...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sheng, Ren, Jung, Da-Jung, Silkov, Antonina, Kim, Hyunjin, Singaram, Indira, Wang, Zhi-Gang, Xin, Yao, Kim, Eui, Park, Mi-Jeong, Thiagarajan-Rosenkranz, Pallavi, Smrt, Sean, Honig, Barry, Baek, Kwanghee, Ryu, Sungho, Lorieau, Justin, Kim, You-Me, Cho, Wonhwa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016160/
https://ncbi.nlm.nih.gov/pubmed/27334919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720284
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