SH2 domains serve as lipid binding modules for pTyr-signaling proteins

The Src-homology 2 (SH2) domain is a protein interaction domain that directs myriad phosphotyrosine (pY) signaling pathways. Genome-wide screening of human SH2 domains reveals that ≈90% of SH2 domains bind plasma membrane lipids and many have high phosphoinositide specificity. They bind lipids using...

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Publicado no:Mol Cell
Principais autores: Park, Mi-Jeong, Sheng, Ren, Silkov, Antonina, Jung, Da-Jung, Wang, Zhi-Gang, Xin, Yao, Kim, Hyunjin, Thiagarajan-Rosenkranz, Pallavi, Song, Seohyeon, Yoon, Youngdae, Nam, Wonhee, Kim, Ilshin, Kim, Eui, Lee, Dong-Gyu, Chen, Yong, Singaram, Indira, Wang, Li, Jang, Myoung Ho, Hwang, Cheol-Sang, Honig, Barry, Ryu, Sungho, Lorieau, Justin, Kim, You-Me, Cho, Wonhwa
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826312/
https://ncbi.nlm.nih.gov/pubmed/27052731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.01.027
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