Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

Eitemau Tebyg

• Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn
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• Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain
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• CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1
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• Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
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• Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.
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