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Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

CD28 costimulation is required for the generation of naturally derived regulatory T cells (nTregs) in the thymus through lymphocyte-specific protein tyrosine kinase (Lck) signaling. However, it is not clear how CD28 costimulation regulates the generation of induced Tregs (iTregs) from naive CD4 T-ce...

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Bibliografiske detaljer
Main Authors: Semple, Kenrick, Nguyen, Antony, Yu, Yu, Wang, Honglin, Anasetti, Claudio, Yu, Xue-Zhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062312/
https://ncbi.nlm.nih.gov/pubmed/21245484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-301275
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