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CD28 Costimulation is Essential for Human T Regulatory Expansion and Function
The costimulatory requirements required for peripheral blood T regulatory cells (Tregs) are unclear. Using cell-based artificial APCs (aAPC) we found that CD28, but not ICOS, OX40, 4-1BB, CD27, or CD40-L costimulation, maintained high levels of Foxp3 expression and in vitro suppressive function. Onl...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556987/ https://ncbi.nlm.nih.gov/pubmed/18684977 |
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