CD28 Costimulation is Essential for Human T Regulatory Expansion and Function

The costimulatory requirements required for peripheral blood T regulatory cells (Tregs) are unclear. Using cell-based artificial APCs (aAPC) we found that CD28, but not ICOS, OX40, 4-1BB, CD27, or CD40-L costimulation, maintained high levels of Foxp3 expression and in vitro suppressive function. Onl...

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Autores principales: Golovina, Tatiana N., Mikheeva, Tatiana, Suhoski, Megan M., Aqui, Nicole A., Tai, Victoria C., Shan, Xiaochuan, Liu, Ronghua, Balcarcel, R. Robert, Fisher, Nancy, Levine, Bruce L., Carroll, Richard G., Warner, Noel, Blazar, Bruce R., June, Carl H., Riley, James L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556987/
https://ncbi.nlm.nih.gov/pubmed/18684977
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