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Role of CD28, CTLA4 and ICOS costimulation in Acute Graft-versus-Host Disease in Mice
T cells deficient for CD28 have reduced ability to expand and survive, but still cause graft-versus-host disease (GVHD). Inducible costimulator (ICOS), the third member of the CD28 family, is expressed on antigen-activated T cells and has unique roles in T-cell activation and effector function. We h...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131782/ https://ncbi.nlm.nih.gov/pubmed/21447398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2011.01.018 |
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