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Phosphatidylinositol 3-Kinase–Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice

We and others have previously shown that ICOS plays an important role in inducing acute graft-versus-host disease (GVHD) in murine models of allogeneic bone marrow transplantation. ICOS potentiates TCR-mediated PI3K activation and intracellular calcium mobilization. However, ICOS signal transduction...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Li, Jun, Heinrichs, Jessica, Leconte, Julien, Haarberg, Kelley, Semple, Kenrick, Liu, Chen, Gigoux, Mathieu, Kornete, Mara, Piccirillo, Ciriaco A., Suh, Woong-Kyung, Yu, Xue-Zhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318500/
https://ncbi.nlm.nih.gov/pubmed/23729441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203485
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