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Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

A previously undescribed 62-kDa protein (p62) that does not contain phosphotyrosine but, nevertheless, binds specifically to the isolated src homology 2 (SH2) domain of p56lck has been identified. The additional presence of the unique N-terminal region of p56lck prevents p62 binding to the SH2 domai...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Park, I, Chung, J, Walsh, C T, Yun, Y, Strominger, J L, Shin, J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40352/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8618896/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.26.12338
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