Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

During T-cell activation, Ser59 in the unique N-terminal region of p56lck is phosphorylated. Mutation of Ser59 to Glu59 mimics Ser59 phosphorylation, and upon CD4 crosslinking, this mutant p56lck induces tyrosine phosphorylation of intracellular proteins distinct from those induced by wild-type p56l...

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Detalhes bibliográficos
Main Authors: Joung, I, Kim, T, Stolz, L A, Payne, G, Winkler, D G, Walsh, C T, Strominger, J L, Shin, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC41584/
https://ncbi.nlm.nih.gov/pubmed/7597029
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