Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

During T-cell activation, Ser59 in the unique N-terminal region of p56lck is phosphorylated. Mutation of Ser59 to Glu59 mimics Ser59 phosphorylation, and upon CD4 crosslinking, this mutant p56lck induces tyrosine phosphorylation of intracellular proteins distinct from those induced by wild-type p56l...

Description complète

Détails bibliographiques

Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Joung, I, Kim, T, Stolz, L A, Payne, G, Winkler, D G, Walsh, C T, Strominger, J L, Shin, J
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41584/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7597029/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.13.5778
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!