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Membrane association of the CD3ε signaling domain is required for optimal T cell development and function()
The T cell receptor (TCR):CD3 complex transduces signals that are critical for optimal T cell development and adaptive immunity. In resting T cells, the CD3ε cytoplasmic tail associates with the plasma membrane via a proximal basic-rich stretch (BRS). Here we show that mice lacking a functional CD3ε...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4065803/ https://ncbi.nlm.nih.gov/pubmed/24899501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400322 |
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