Regulation of T cell Receptor Activation by Dynamic Membrane Binding of the CD3ε Cytoplasmic Tyrosine-Based Motif

Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs), but how receptor ligation results in ITAM phosphorylation remains unknown. Live cell imaging studies showed a close interaction of the CD3ε cytoplasmic domain of the T cell receptor (TCR) with the plasma membrane...

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Detalhes bibliográficos
Main Authors: Xu, Chenqi, Gagnon, Etienne, Call, Matthew E., Schnell, Jason R., Schwieters, Charles D., Carman, Christopher V., Chou, James J., Wucherpfennig, Kai W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597348/
https://ncbi.nlm.nih.gov/pubmed/19013279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.044
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