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CD3 ITAM diversity is required for optimal T cell receptor signaling and thymocyte development
In order for the αβ or γδT cell receptor chains (TCR) to integrate extracellular stimuli into the appropriate intracellular cellular response, they must utilize the 10 immunoreceptor tyrosine-based activation motifs (ITAMs) found within the CD3 subunits CD3γε, CD3δε, and ζζ) of the TCR signaling com...
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| Publicado en: | J Immunol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568475/ https://ncbi.nlm.nih.gov/pubmed/28733484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700069 |
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