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CD3 ITAM diversity is required for optimal T cell receptor signaling and thymocyte development

In order for the αβ or γδT cell receptor chains (TCR) to integrate extracellular stimuli into the appropriate intracellular cellular response, they must utilize the 10 immunoreceptor tyrosine-based activation motifs (ITAMs) found within the CD3 subunits CD3γε, CD3δε, and ζζ) of the TCR signaling com...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Bettini, Matthew L., Chou, Po-Chein, Guy, Clifford, Lee, Thomas, Vignali, Kate M., Vignali, Dario A.A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568475/
https://ncbi.nlm.nih.gov/pubmed/28733484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700069
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