Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

The T cell costimulatory receptor CD28 is required for the full activation of naïve T cells and for the development and maintenance of Foxp3(+) regulatory T (T(reg)) cells. We showed that the cytoplasmic domain of CD28 was bound to the plasma membrane in resting cells and that ligand binding to CD28...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Dobbins, Jessica, Gagnon, Etienne, Godec, Jernej, Pyrdol, Jason, Vignali, Dario A. A., Sharpe, Arlene H., Wucherpfennig, Kai W.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929992/
https://ncbi.nlm.nih.gov/pubmed/27460989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf0626
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