Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury

Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro–nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Ryu, Jae Cheon, Tooke, Katharine, Malley, Susan E., Soulas, Anastasia, Weiss, Tirzah, Ganesh, Nisha, Saidi, Nabila, Daugherty, Stephanie, Saragovi, Uri, Ikeda, Youko, Zabbarova, Irina, Kanai, Anthony J., Yoshiyama, Mitsuharu, Farhadi, H. Francis, de Groat, William C., Vizzard, Margaret A., Yoon, Sung Ok
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919823/
https://ncbi.nlm.nih.gov/pubmed/29584618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97837
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