Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury

Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro–nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Ryu, Jae Cheon, Tooke, Katharine, Malley, Susan E., Soulas, Anastasia, Weiss, Tirzah, Ganesh, Nisha, Saidi, Nabila, Daugherty, Stephanie, Saragovi, Uri, Ikeda, Youko, Zabbarova, Irina, Kanai, Anthony J., Yoshiyama, Mitsuharu, Farhadi, H. Francis, de Groat, William C., Vizzard, Margaret A., Yoon, Sung Ok
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919823/
https://ncbi.nlm.nih.gov/pubmed/29584618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97837
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