Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood–retina barrier breakdown in mice and rats

AIMS/HYPOTHESIS: Diabetic retinopathy is characterised by early blood–retina barrier (BRB) breakdown and neurodegeneration. Diabetes causes imbalance of nerve growth factor (NGF), leading to accumulation of the NGF precursor (proNGF), as well as the NGF receptor, p75 neurotrophin receptor (p75(NTR))...

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Main Authors: Mysona, Barbara A., Al-Gayyar, Mohammed M.H., Matragoon, Suraporn, Abdelsaid, Mohammed A., El-Azab, Mona F., Saragovi, H. Uri, El-Remessy, Azza B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791887/
https://ncbi.nlm.nih.gov/pubmed/23918145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2998-6
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