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Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
Nerve growth factor is initially synthesized as a precursor, proNGF, which is cleaved to release its C-terminal mature form. Recent studies suggest that proNGF is not an inactive precursor, but acts as a signaling ligand distinct from its mature counterpart. Pro- and mature NGF initiate opposing bio...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847487/ https://ncbi.nlm.nih.gov/pubmed/20036257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.12.030 |
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