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Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin

Nerve growth factor is initially synthesized as a precursor, proNGF, which is cleaved to release its C-terminal mature form. Recent studies suggest that proNGF is not an inactive precursor, but acts as a signaling ligand distinct from its mature counterpart. Pro- and mature NGF initiate opposing bio...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Feng, Dan, Kim, Taeho, Özkan, Engin, Light, Matthew, Torkin, Risa, Teng, Kenneth K., Hempstead, Barbara L., Garcia, K. Christopher
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847487/
https://ncbi.nlm.nih.gov/pubmed/20036257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.12.030
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