Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury

Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro–nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ryu, Jae Cheon, Tooke, Katharine, Malley, Susan E., Soulas, Anastasia, Weiss, Tirzah, Ganesh, Nisha, Saidi, Nabila, Daugherty, Stephanie, Saragovi, Uri, Ikeda, Youko, Zabbarova, Irina, Kanai, Anthony J., Yoshiyama, Mitsuharu, Farhadi, H. Francis, de Groat, William C., Vizzard, Margaret A., Yoon, Sung Ok
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919823/
https://ncbi.nlm.nih.gov/pubmed/29584618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97837
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