Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury

Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro–nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Ryu, Jae Cheon, Tooke, Katharine, Malley, Susan E., Soulas, Anastasia, Weiss, Tirzah, Ganesh, Nisha, Saidi, Nabila, Daugherty, Stephanie, Saragovi, Uri, Ikeda, Youko, Zabbarova, Irina, Kanai, Anthony J., Yoshiyama, Mitsuharu, Farhadi, H. Francis, de Groat, William C., Vizzard, Margaret A., Yoon, Sung Ok
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919823/
https://ncbi.nlm.nih.gov/pubmed/29584618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97837
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