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HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. The exact cellular stage at which HOXB4 promotes hematopoiet...

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Publicat a:Stem Cell Reports
Autors principals: Teichweyde, Nadine, Kasperidus, Lara, Carotta, Sebastian, Kouskoff, Valerie, Lacaud, Georges, Horn, Peter A., Heinrichs, Stefan, Klump, Hannes
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919293/
https://ncbi.nlm.nih.gov/pubmed/29456178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.009
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