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HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

Summary: Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. The exact cellular stage at which HOXB4 promotes he...

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Main Authors: Nadine Teichweyde, Lara Kasperidus, Sebastian Carotta, Valerie Kouskoff, Georges Lacaud, Peter A. Horn, Stefan Heinrichs, Hannes Klump
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018-03-01
Series:Stem Cell Reports
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2213671118300353
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