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HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. The exact cellular stage at which HOXB4 promotes hematopoiet...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Teichweyde, Nadine, Kasperidus, Lara, Carotta, Sebastian, Kouskoff, Valerie, Lacaud, Georges, Horn, Peter A., Heinrichs, Stefan, Klump, Hannes
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919293/
https://ncbi.nlm.nih.gov/pubmed/29456178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.009
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