Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process

During large-scale monoclonal antibody manufacturing, disulfide bond reduction of antibodies, which results in generation of low molecule weight species, is occasionally observed. When this happens, the drug substance does not meet specifications. Many investigations have been conducted across the b...

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Vydáno v:MAbs
Hlavní autoři: Du, Cheng, Huang, Yunping, Borwankar, Ameya, Tan, Zhijun, Cura, Anthony, Yee, Joon Chong, Singh, Nripen, Ludwig, Richard, Borys, Michael, Ghose, Sanchayita, Mussa, Nesredin, Li, Zheng Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916552/
https://ncbi.nlm.nih.gov/pubmed/29336721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1424609
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