Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody biophysical properties, a clear gap still exists betwee...

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Detalhes bibliográficos
Main Authors: Zhiqiang Chen, Yueming Qian, Yuanli Song, Xuankuo Xu, Li Tao, Nesredin Mussa, Sanchayita Ghose, Zheng Jian Li
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
Colecção:mAbs
Assuntos:
therapeutic IgG4
single-point mutation
manufacturability
bioprocessing
bioanalysis
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2020.1829338
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