Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process

During large-scale monoclonal antibody manufacturing, disulfide bond reduction of antibodies, which results in generation of low molecule weight species, is occasionally observed. When this happens, the drug substance does not meet specifications. Many investigations have been conducted across the b...

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發表在:MAbs
Main Authors: Du, Cheng, Huang, Yunping, Borwankar, Ameya, Tan, Zhijun, Cura, Anthony, Yee, Joon Chong, Singh, Nripen, Ludwig, Richard, Borys, Michael, Ghose, Sanchayita, Mussa, Nesredin, Li, Zheng Jian
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916552/
https://ncbi.nlm.nih.gov/pubmed/29336721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1424609
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